Vardenafil impurity E
2-Ethoxybenzamidine hydrochloride
CAS: 18637-00-8
Molecular Formula: C9H13ClN2O
Vardenafil impurity E - Names and Identifiers
Vardenafil impurity E - Physico-chemical Properties
| Molecular Formula | C9H13ClN2O |
| Molar Mass | 200.67 |
| Density | 1.213 |
| Melting Point | 132 - 137oC |
| Boling Point | 192°C at 760 mmHg |
| Flash Point | 66.7°C |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 0.001-0.657Pa at 20-96.23℃ |
| Appearance | Solid |
| Color | White to Off-White |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.552 |
Vardenafil impurity E - Reference Information
| surface tension | 62.9mN/m at 1g/L and 20 ℃ |
| introduction | 2-ethoxybenzamidine hydrochloride is a pharmaceutical intermediate, which can be prepared from 2-ethoxybenzonitrile in one step. It has been reported that 2-ethoxybenzamidine hydrochloride can be used to prepare phosphodiesterase inhibitors. |
| Preparation | Suspend 21.4g(400 mmol) ammonium chloride in 375 ml toluene and cool the suspension to 0°C. Drop 200 ml of 2M trimethylaluminum hexane solution and stir the mixture at room temperature until the escape of the gas has stopped. 29.44g(200mmol) of 2-ethoxybenzonitrile was added, and then the reaction mixture was stirred overnight at 80°C (bath). The cooled reaction mixture was added to a suspension of 100g silica gel and 950ml chloroform under ice cold, and the mixture was stirred at room temperature for 30 minutes. The mixture was pumped out and the filter residue was washed with the same amount of methanol. Evaporate the mother liquor, stir the resulting residue with a mixture of dichloromethane and methanol (9:1), filter the solids, and evaporate the mother liquor. 30.4g(76%) colorless solid was obtained. |
Last Update：2024-04-09 19:05:10
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Product Name: 2-Ethoxybenzamidine hydrochloride Request for quotationCAS: 18637-00-8
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Mobile: 18162425036
QQ: 3866263148
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Product Name: 2-Ethoxybenzamidine hydrochloride Visit Supplier Webpage Request for quotation
CAS: 18637-00-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 18637-00-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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